HUMAN ENDOGENOUS LIPEMIA CLEARING ACTIVITY

The Inhibition of Lipemia-clearing

It was recently shown in this laboratory (1) that in idiopathic hyperlipemia the elimination of lipids from the blood stream following an intravenous infusion of a fat emulsion is considerably delayed, indicating a defect of the lipemiaclearing mechanism in these patients. It was then found that the clearing activity present in the serum of normal human subjects who have received heparin was in...

Absence of lipemia clearing factor lipase in human adipose tissue.

Lipoprotein lipase, or lipemia clearing factor lipase (which is more accurate terminology [l]) , is a heparin-activated enzyme which has been found in rat, beef, and pig heart (2). The adipose tissues of rats, rabbits, and especially chickens contain greater quantities of the enzyme (3). This latter observation led to the suggestion that the major site of lipoprotein lipase activity was in the ...

Clearing factor inhibitor in human atherosclerosis.

A reductioii in leparin-activated clearing factor has been demonistrated in individuals with atheroselerosis or conditions related to it. The recent isolation fromn normal plasmlla of an inhibitor to clearing factor suggested that the reduction described mllight be due to .in increased level of inhibitor. This possibility was therefore investigated by determiiiilug the inhibitor efTect of tile ...

The alteration of the lipemia-clearing effect of heparin following the intravenous injection of thorium dioxide (thorotrast).

Human Endogenous Retrovirus W Activity in Cartilage of Osteoarthritis Patients

The etiology of viruses in osteoarthritis remains controversial because the prevalence of viral nucleic acid sequences in peripheral blood or synovial fluid from osteoarthritis patients and that in healthy control subjects are similar. Until now the presence of virus has not been analyzed in cartilage. We screened cartilage and chondrocytes from advanced and non-/early osteoarthritis patients f...